Well i have a smaller 1600ax on my completly stock 454 and with my headers and exhaust i produce about 5 lbs boost, i have towed with it and had not any issues, (approx 10,000lbs) I`m not quite the guru of building engines but it sounds like you will be able to handle that boost, (contact lunati about the cam, they know best.) if you install a pyrometer it should be able to notify you prior to any disasters. do note that our engine computers are able to back off timing as required when detonation occurs. worst case scenario is to install a smaller pulley or maybe a custom made one that reduces boost by a pound or two.
As for the intercooling i have pondered this much aswell, due to the small inlet size and shape on the manifold not much is going to fit. however running a water injection setup may be an option. I have always pondered running a second exhanger off of the air conditioning system right after the air filter, how ever this would take up alot of space and place an extra load on the conditioning system ultimatly reducing radiator efficiency. I sure wish i could have more time and money to fool around with it, i could be onto something!!
lol.
Not sure if i helped you out much, but good luck on the project!